HIV-particles in spermatozoa of patients with AIDS and their transfer into the oocyte.
J Cell Biol
; 127(4): 903-14, 1994 Nov.
Article
in En
| MEDLINE
| ID: mdl-7962075
ABSTRACT
By immunocytochemistry and in situ hybridization at the electron microscopy level, and by the PCR technique, we have shown that HIV-1 binds and enters normal sperm; that viral particles, their antigens, and nucleic acid are present in sperm from HIV-1 infected men; and that such sperm can transfer HIV-1 like particles to normal human oocytes. We also present evidence that a galactosylceramide-like compound is present on the sperm membrane and could function as an alternative receptor for HIV.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oocytes
/
Spermatozoa
/
Acquired Immunodeficiency Syndrome
/
HIV-1
/
Disease Transmission, Infectious
/
Fertilization
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
J Cell Biol
Year:
1994
Type:
Article
Affiliation country:
Italy