Production of PEG-modified bovine hemoglobin: economics and feasibility.

Bradley, R; Sloshberg, S; Nho, K; Czuba, B; Szesko, D; Shorr, R

Bradley, R; Sloshberg, S; Nho, K; Czuba, B; Szesko, D; Shorr, R.

Affiliation

Bradley R; Enzon, Inc., Piscataway, NJ 08854.

Artif Cells Blood Substit Immobil Biotechnol ; 22(3): 657-67, 1994.

Article in En | MEDLINE | ID: mdl-7994387

ABSTRACT

ABSTRACT

Bovine hemoglobin has many advantages as a blood substitute a) it's ready availability; b) it's low cost; c) it's oxygen carrying capacity; and d) the ease with which it can be modified with polyethylene glycol (PEG) to improve its pharmacokinetic profile. This study investigates the potential of PEG-modified bovine hemoglobin as a cost-effective blood substitute.

Subject(s)

Blood Substitutes/economics; Blood Substitutes/isolation & purification; Hemoglobins/isolation & purification; Polyethylene Glycols; Animals; Blood Substitutes/chemistry; Cattle; Chromatography, High Pressure Liquid; Cost-Benefit Analysis; Drug Contamination; Drug Stability; Endotoxins/analysis; Exchange Transfusion, Whole Blood; Hemoglobins/metabolism; Hemoglobinuria/etiology; Humans; In Vitro Techniques; Methemoglobin/analysis; Oxygen/metabolism; Rats; Shock/metabolism; Shock/therapy

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Collection: 01-internacional Database: MEDLINE Main subject: Polyethylene Glycols / Blood Substitutes / Hemoglobins Type of study: Etiology_studies / Health_economic_evaluation Limits: Animals / Humans Language: En Journal: Artif Cells Blood Substit Immobil Biotechnol Journal subject: BIOTECNOLOGIA / TRANSPLANTE Year: 1994 Type: Article

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