[Effect of anti-aging drug on the activity of DNA methylase in rat liver].

He, Z X; Wei, W; Wu, Z K

He, Z X; Wei, W; Wu, Z K.

Affiliation

He ZX; Dept. of Biology, Beijing Normal University.

Zhongguo Zhong Xi Yi Jie He Za Zhi ; 14(6): 354-6, 325-6, 1994 Jun.

Article in Zh | MEDLINE | ID: mdl-8000226

ABSTRACT

ABSTRACT

An obvious anti-aging effect was found by Bushen Shengxue drug to treat Wistar rats. Using a method about incorporation of 3H-labeled methyl group of S-adenosyl-methionine (SAM) into DNA bases, the DNA methylase activity was assayed. The specific activity of DNA methylase was increased by treatment of this drug. The chromatographic behaviour of DNA methylase from rat liver was also changed. These results showed that the mechanism of anti-aging effect of this drug is probably related to DNA methylation.

Subject(s)

Aging/drug effects; DNA Modification Methylases/metabolism; Drugs, Chinese Herbal/pharmacology; Liver/enzymology; Animals; Male; Rats; Rats, Wistar

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Collection: 01-internacional Database: MEDLINE Main subject: Aging / Drugs, Chinese Herbal / DNA Modification Methylases / Liver Limits: Animals Language: Zh Journal: Zhongguo Zhong Xi Yi Jie He Za Zhi Journal subject: TERAPIAS COMPLEMENTARES Year: 1994 Type: Article

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