Similar sequence specificity of mitoxantrone and VM-26 stimulation of in vitro DNA cleavage by mammalian DNA topoisomerase II.

Capranico, G; De Isabella, P; Tinelli, S; Bigioni, M; Zunino, F

Capranico, G; De Isabella, P; Tinelli, S; Bigioni, M; Zunino, F.

Affiliation

Capranico G; Division of Experimental Oncology B, Istituto nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.

Biochemistry ; 32(12): 3038-46, 1993 Mar 30.

Article in En | MEDLINE | ID: mdl-8384486

Subject(s)

DNA Topoisomerases, Type II/metabolism; DNA/metabolism; Mitoxantrone/pharmacology; Teniposide/pharmacology; Amsacrine/pharmacology; Animals; Base Sequence; Binding Sites; DNA, Viral/metabolism; Electrophoresis, Agar Gel; Idarubicin/pharmacology; Leukemia P388/enzymology; Mice; Molecular Sequence Data; Mutagenesis; Oligodeoxyribonucleotides/metabolism; Simian virus 40/genetics; Substrate Specificity; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Teniposide / DNA / Mitoxantrone / DNA Topoisomerases, Type II Limits: Animals Language: En Journal: Biochemistry Year: 1993 Type: Article Affiliation country: Italy

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