The methylation status of the major breakpoint cluster region in human leukemia cells, including Philadelphia chromosome-positive cells, is linked to the lineage of hematopoietic cells.

Ohyashiki, J H; Ohyashiki, K; Kawakubo, K; Tauchi, T; Shimamoto, T; Toyama, K

Ohyashiki, J H; Ohyashiki, K; Kawakubo, K; Tauchi, T; Shimamoto, T; Toyama, K.

Affiliation

Ohyashiki JH; First Department of Internal Medicine, Tokyo Medical College, Japan.

Leukemia ; 7(6): 801-7, 1993 Jun.

Article in En | MEDLINE | ID: mdl-8501975

Subject(s)

Cytosine/analogs & derivatives; Hematopoiesis; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics; Protein-Tyrosine Kinases; Proto-Oncogene Proteins/genetics; 5-Methylcytosine; Cytosine/metabolism; DNA, Neoplasm/genetics; Granulocytes/pathology; Hematopoietic Stem Cells/pathology; Humans; In Vitro Techniques; Methylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology; Proto-Oncogene Proteins c-bcr; Restriction Mapping; Translocation, Genetic; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Proto-Oncogene Proteins / Cytosine / Hematopoiesis Limits: Humans Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 1993 Type: Article Affiliation country: Japan

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