The effect of treatment on lymphokine-secreting cells in the intestinal mucosa of children with Crohn's disease.
Aliment Pharmacol Ther
; 9(5): 547-52, 1995 Oct.
Article
in En
| MEDLINE
| ID: mdl-8580276
ABSTRACT
BACKGROUND:
Recent studies have shown both interleukin 2 (IL-2) and interferon gamma (IFN) to be elevated in patients with active Crohn's disease compared to ulcerative colitis or non-inflammatory bowel disease controls. However the effect of treatment on these lymphokines has not been studied. PATIENTS ANDMETHODS:
Using a reverse haemolytic plaque assay the percentage of lymphokine-secreting cells was determined in the intestinal mucosa of children with Crohn's disease before and after 8 weeks of treatment with either enteral nutrition, cyclosporin or steroids.RESULTS:
Before treatment, a high percentage of cells isolated from mucosal biopsies secreted IL-2 or interferon-gamma. Eight weeks' treatment with the immunosuppressive agents cyclosporin, or with corticosteroids, produced a significant reduction in the percentage of IL-2 secreting cells, although only for the former was there also a reduction in interferon-gamma secreting cells. Enteral nutrition however, produced a reduction in lymphokine-secreting cells equivalent to cyclosporin and produced the best histological and clinical improvement.CONCLUSION:
Enteral nutrition and cyclosporin can down-regulate lymphokine secretion in the gut in Crohn's disease.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prednisolone
/
T-Lymphocytes
/
Crohn Disease
/
Interferon-gamma
/
Interleukin-2
/
Cyclosporine
/
Immunosuppressive Agents
/
Intestinal Mucosa
/
Anti-Inflammatory Agents
Type of study:
Clinical_trials
Limits:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Language:
En
Journal:
Aliment Pharmacol Ther
Journal subject:
FARMACOLOGIA
/
GASTROENTEROLOGIA
/
TERAPIA POR MEDICAMENTOS
Year:
1995
Type:
Article
Affiliation country:
United kingdom