Inhibition of chondrocyte cathepsin B and L activities by insulin-like growth factor-II (IGF-II) and its Ser29 variant in vitro: possible role of the mannose 6-phosphate/IGF-II receptor.

De Ceuninck, F; Poiraudeau, S; Pagano, M; Tsagris, L; Blanchard, O; Willeput, J; Corvol, M

De Ceuninck, F; Poiraudeau, S; Pagano, M; Tsagris, L; Blanchard, O; Willeput, J; Corvol, M.

Affiliation

De Ceuninck F; Institut National de la Santé et de la Recherche Médicale, U 30, Paris, France.

Mol Cell Endocrinol ; 113(2): 205-13, 1995 Sep 22.

Article in En | MEDLINE | ID: mdl-8674828

Subject(s)

Cartilage/enzymology; Cathepsin B/antagonists & inhibitors; Cathepsins/antagonists & inhibitors; Endopeptidases; Enzyme Inhibitors/pharmacology; Insulin-Like Growth Factor II/pharmacology; Receptor, IGF Type 2/physiology; Animals; Cathepsin L; Cell Membrane/metabolism; Cells, Cultured; Cysteine Endopeptidases; Insulin/pharmacology; Insulin-Like Growth Factor I/metabolism; Insulin-Like Growth Factor I/pharmacology; Insulin-Like Growth Factor II/metabolism; Kinetics; Rabbits

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Collection: 01-internacional Database: MEDLINE Main subject: Endopeptidases / Insulin-Like Growth Factor II / Cathepsin B / Cartilage / Cathepsins / Receptor, IGF Type 2 / Enzyme Inhibitors Limits: Animals Language: En Journal: Mol Cell Endocrinol Year: 1995 Type: Article Affiliation country: France

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