Voluntary chronic exercise augments in vivo natural immunity in rats.
J Appl Physiol (1985)
; 80(5): 1799-803, 1996 May.
Article
in En
| MEDLINE
| ID: mdl-8727569
ABSTRACT
The effect of chronic voluntary exercise on the immune response was studied in spontaneously hypertensive rats. Exercise consisted of voluntary running in wheels for 5 wk, and the mean running distance was 4.2 km/24 h. In vivo cytotoxicity was measured as clearance of injected 51Cr-labeled YAC-1 lymphoma cells from the lungs. The clearance of YAC-1 cells in vivo was significantly increased in runners compared with sedentary controls (P < 0.001). The total number of mononuclear cells in the spleen was significantly decreased in runners compared with controls. Analysis of splenic lymphocyte phenotypes revealed a significantly increased fraction of OX52+/CD5- natural killer cells in runners compared with sedentary controls. In contrast to changes in natural immunity, immunoglobulins G and M levels in serum, the antibody response to antigen in vivo, and the proliferation of splenic T cells in vitro were unchanged. Our data suggest that chronic voluntary exercise augments natural cytotoxicity mechanisms in vivo, whereas splenic T-cell proliferation and the antibody-mediated immune response remain unchanged.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immunoglobulin G
/
Immunoglobulin M
/
Lymphoma
/
Motor Activity
Limits:
Animals
Language:
En
Journal:
J Appl Physiol (1985)
Journal subject:
FISIOLOGIA
Year:
1996
Type:
Article
Affiliation country:
Sweden