Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrheagenicity but retain adjuvanticity.

Yamamoto, S; Takeda, Y; Yamamoto, M; Kurazono, H; Imaoka, K; Yamamoto, M; Fujihashi, K; Noda, M; Kiyono, H; McGhee, J R

Yamamoto, S; Takeda, Y; Yamamoto, M; Kurazono, H; Imaoka, K; Yamamoto, M; Fujihashi, K; Noda, M; Kiyono, H; McGhee, J R.

Affiliation

Yamamoto S; Immunobiology Vaccine Center and Department of Microbiology, University of Alabama at Birmingham, 35294, USA.

J Exp Med ; 185(7): 1203-10, 1997 Apr 07.

Article in En | MEDLINE | ID: mdl-9104807

Subject(s)

Adjuvants, Immunologic/toxicity; Cholera Toxin/toxicity; Diarrhea; Mutation; Poly(ADP-ribose) Polymerases/genetics; Animals; CD4-Positive T-Lymphocytes/immunology; CHO Cells; Cholera Toxin/genetics; Cricetinae; Cyclic AMP; Cytokines/biosynthesis; Dose-Response Relationship, Drug; Ileum/drug effects; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mucous Membrane/immunology; Th2 Cells/immunology; Toxicity Tests

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adjuvants, Immunologic / Cholera Toxin / Poly(ADP-ribose) Polymerases / Diarrhea / Mutation Limits: Animals Language: En Journal: J Exp Med Year: 1997 Type: Article Affiliation country: United States

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