5-HT1A and 5-HT2A receptor affinity and functional profile of some N-[3-(4-aryl-1-piperazinyl)propyl] derivatives of indolin-2(1H)-one, quinolin-2(1 H)-one and isoquinolin-1(2H)-one. Part 30: Structure-activity relationship studies of CNS agents.

Mokrosz, M J; Mokrosz, J L; Duszynska, B; Deren-Wesolek, A; Klodzinska, A; Kowalski, P; Charakchieva-Minol, S; Tatarczynska, E; Kowalska, T; Majka, Z; Chojnacka-Wójcik, E; Misztal, S

Mokrosz, M J; Mokrosz, J L; Duszynska, B; Deren-Wesolek, A; Klodzinska, A; Kowalski, P; Charakchieva-Minol, S; Tatarczynska, E; Kowalska, T; Majka, Z; Chojnacka-Wójcik, E; Misztal, S.

Affiliation

Mokrosz MJ; Department of Medicinal Chemistry, Polish Academy of Sciences, Kraków, Poland.

Pharmazie ; 52(6): 423-8, 1997 Jun.

Article in En | MEDLINE | ID: mdl-9260266

Subject(s)

Indoles/chemical synthesis; Isoquinolines/chemical synthesis; Piperazines/chemical synthesis; Quinolones/chemical synthesis; Receptors, Serotonin/metabolism; Serotonin Antagonists/chemical synthesis; Serotonin Receptor Agonists/chemical synthesis; 8-Hydroxy-2-(di-n-propylamino)tetralin/metabolism; Amphetamines/antagonists & inhibitors; Amphetamines/pharmacology; Animals; Behavior, Animal/drug effects; Binding, Competitive/drug effects; Chemical Phenomena; Chemistry, Physical; Hippocampus/drug effects; Hippocampus/metabolism; In Vitro Techniques; Indoles/pharmacology; Isoquinolines/pharmacology; Ketanserin/metabolism; Kinetics; Male; Mice; Piperazines/pharmacology; Quinolones/pharmacology; Radioligand Assay; Rats; Rats, Wistar; Receptors, Serotonin/drug effects; Serotonin Antagonists/pharmacology; Serotonin Receptor Agonists/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Serotonin Antagonists / Receptors, Serotonin / Serotonin Receptor Agonists / Quinolones / Indoles / Isoquinolines Limits: Animals Language: En Journal: Pharmazie Journal subject: FARMACIA Year: 1997 Type: Article Affiliation country: Poland

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