Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.

Anizon, F; Belin, L; Moreau, P; Sancelme, M; Voldoire, A; Prudhomme, M; Ollier, M; Sevère, D; Riou, J F; Bailly, C; Fabbro, D; Meyer, T

Anizon, F; Belin, L; Moreau, P; Sancelme, M; Voldoire, A; Prudhomme, M; Ollier, M; Sevère, D; Riou, J F; Bailly, C; Fabbro, D; Meyer, T.

Affiliation

Anizon F; Synthèse, Electrosynthèse et Etude de Systèmes à Intérêt Biologique, Université Blaise Pascal, UMR 6504, Aubière, France.

J Med Chem ; 40(21): 3456-65, 1997 Oct 10.

Article in En | MEDLINE | ID: mdl-9341921

Subject(s)

Aminoglycosides; Anti-Bacterial Agents/chemical synthesis; Anti-Bacterial Agents/pharmacology; Antibiotics, Antineoplastic/chemical synthesis; Carbazoles; Indoles; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Animals; Anti-Bacterial Agents/chemistry; Anti-Bacterial Agents/toxicity; Antibiotics, Antineoplastic/pharmacology; Antibiotics, Antineoplastic/toxicity; Cell Division/drug effects; DNA/chemistry; DNA/drug effects; DNA/metabolism; DNA Footprinting; DNA Ligases/antagonists & inhibitors; DNA Ligases/metabolism; Drug Screening Assays, Antitumor; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/pharmacology; Enzyme Inhibitors/toxicity; Mice; Microbial Sensitivity Tests; Molecular Structure; Monosaccharides/chemistry; Protein Kinase C/antagonists & inhibitors; Structure-Activity Relationship; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Carbazoles / Topoisomerase I Inhibitors / Topoisomerase II Inhibitors / Aminoglycosides / Indoles / Anti-Bacterial Agents / Antibiotics, Antineoplastic Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1997 Type: Article Affiliation country: France

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