Prevention of immunotoxin-induced immunogenicity by coadministration with CTLA4Ig enhances antitumor efficacy.

Siegall, C B; Haggerty, H G; Warner, G L; Chace, D; Mixan, B; Linsley, P S; Davidson, T

Siegall, C B; Haggerty, H G; Warner, G L; Chace, D; Mixan, B; Linsley, P S; Davidson, T.

Affiliation

Siegall CB; Molecular Immunology Department, Bristol-Myers Squibb Pharmaceutical Research Institute, Syracuse, NY 13057, USA. Clay_B._Siegall@ccmail.bms.com

J Immunol ; 159(10): 5168-73, 1997 Nov 15.

Article in En | MEDLINE | ID: mdl-9366448

Subject(s)

Adjuvants, Immunologic/administration & dosage; Antibodies, Anti-Idiotypic/biosynthesis; Antigens, Differentiation/immunology; Antineoplastic Agents/immunology; Immunoconjugates; Immunoglobulin Fc Fragments/administration & dosage; Immunosuppressive Agents/administration & dosage; Immunotoxins/immunology; Abatacept; Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation/administration & dosage; Antineoplastic Agents/administration & dosage; Antineoplastic Agents/pharmacology; CTLA-4 Antigen; Carcinoma; Colonic Neoplasms; Dogs; Female; Humans; Immunotoxins/administration & dosage; Immunotoxins/metabolism; Immunotoxins/pharmacology; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Mice, Inbred BALB C; Rats; Rats, Inbred BN; Rats, Inbred WF; Recombinant Fusion Proteins/administration & dosage; Recombinant Fusion Proteins/immunology; Recombinant Fusion Proteins/metabolism; Recombinant Fusion Proteins/pharmacology

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin Fc Fragments / Antigens, Differentiation / Adjuvants, Immunologic / Antibodies, Anti-Idiotypic / Immunotoxins / Immunoconjugates / Immunosuppressive Agents / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: J Immunol Year: 1997 Type: Article Affiliation country: United States

Search on Google

XML

PubMed Links