Eliminating a region of respiratory syncytial virus attachment protein allows induction of protective immunity without vaccine-enhanced lung eosinophilia.

Sparer, T E; Matthews, S; Hussell, T; Rae, A J; Garcia-Barreno, B; Melero, J A; Openshaw, P J

Sparer, T E; Matthews, S; Hussell, T; Rae, A J; Garcia-Barreno, B; Melero, J A; Openshaw, P J.

Affiliation

Sparer TE; Imperial College School of Medicine, National Heart and Lung Institute at St. Mary's, London, W2 1PG United Kingdom.

J Exp Med ; 187(11): 1921-6, 1998 Jun 01.

Article in En | MEDLINE | ID: mdl-9607931

Subject(s)

Eosinophilia/chemically induced; HN Protein; Respiratory Syncytial Virus Infections/prevention & control; Respiratory Syncytial Virus, Human/immunology; Viral Proteins/immunology; Viral Vaccines/immunology; Animals; Chromosome Mapping; Female; Humans; Lung/immunology; Mice; Mice, Inbred BALB C; Mutagenesis; Tumor Cells, Cultured; Vaccinia virus; Viral Envelope Proteins; Viral Proteins/genetics; Viral Vaccines/genetics; Weight Loss

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Viral Proteins / Viral Vaccines / HN Protein / Respiratory Syncytial Virus, Human / Respiratory Syncytial Virus Infections / Eosinophilia Limits: Animals / Female / Humans Language: En Journal: J Exp Med Year: 1998 Type: Article

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