Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition.

Pinsky, D J; Liao, H; Lawson, C A; Yan, S F; Chen, J; Carmeliet, P; Loskutoff, D J; Stern, D M

Pinsky, D J; Liao, H; Lawson, C A; Yan, S F; Chen, J; Carmeliet, P; Loskutoff, D J; Stern, D M.

Affiliation

Pinsky DJ; Columbia University College of Physicians and Surgeons, New York 10032, USA. djp5@columbia.edu

J Clin Invest ; 102(5): 919-28, 1998 Sep 01.

Article in En | MEDLINE | ID: mdl-9727060

Subject(s)

Fibrin/metabolism; Gene Expression Regulation/genetics; Hypoxia/physiopathology; Lung/physiopathology; Macrophages/physiology; Plasminogen Activator Inhibitor 1/blood; Plasminogen Activators/antagonists & inhibitors; Animals; Cell Line; Fibrinolysis/physiology; Immunohistochemistry; Male; Mice; Mice, Inbred Strains; Mice, Transgenic; Oxygen/physiology; RNA, Messenger/metabolism; Tissue Plasminogen Activator/metabolism; Urokinase-Type Plasminogen Activator/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fibrin / Plasminogen Activators / Gene Expression Regulation / Plasminogen Activator Inhibitor 1 / Lung / Macrophages / Hypoxia Limits: Animals Language: En Journal: J Clin Invest Year: 1998 Type: Article Affiliation country: United States

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