Design of benzamidine-type inhibitors of factor Xa.

Gabriel, B; Stubbs, M T; Bergner, A; Hauptmann, J; Bode, W; Stürzebecher, J; Moroder, L

Gabriel, B; Stubbs, M T; Bergner, A; Hauptmann, J; Bode, W; Stürzebecher, J; Moroder, L.

Affiliation

Gabriel B; Max-Planck-Institut für Biochemie, Am Klopferspitz 18A, D-82152 Martinsried, Germany.

J Med Chem ; 41(22): 4240-50, 1998 Oct 22.

Article in En | MEDLINE | ID: mdl-9784099

Subject(s)

Benzamidines/chemical synthesis; Factor Xa Inhibitors; Serine Proteinase Inhibitors/chemical synthesis; Animals; Benzamidines/chemistry; Benzamidines/pharmacokinetics; Benzamidines/pharmacology; Binding Sites; Cattle; Crystallography, X-Ray; Humans; Hydrogen Bonding; Rats; Serine Proteinase Inhibitors/chemistry; Serine Proteinase Inhibitors/pharmacokinetics; Serine Proteinase Inhibitors/pharmacology; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Benzamidines / Serine Proteinase Inhibitors / Factor Xa Inhibitors Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1998 Type: Article Affiliation country: Germany

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