Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry.

Rohrer, S P; Birzin, E T; Mosley, R T; Berk, S C; Hutchins, S M; Shen, D M; Xiong, Y; Hayes, E C; Parmar, R M; Foor, F; Mitra, S W; Degrado, S J; Shu, M; Klopp, J M; Cai, S J; Blake, A; Chan, W W; Pasternak, A; Yang, L; Patchett, A A; Smith, R G; Chapman, K T; Schaeffer, J M

Rohrer, S P; Birzin, E T; Mosley, R T; Berk, S C; Hutchins, S M; Shen, D M; Xiong, Y; Hayes, E C; Parmar, R M; Foor, F; Mitra, S W; Degrado, S J; Shu, M; Klopp, J M; Cai, S J; Blake, A; Chan, W W; Pasternak, A; Yang, L; Patchett, A A; Smith, R G; Chapman, K T; Schaeffer, J M.

Affiliation

Rohrer SP; Department of Cell Biochemistry and Physiology, Merck Research Laboratories, Post Office Box 2000, Rahway, NJ 07065, USA. susanvrohrer@merck.com

Science ; 282(5389): 737-40, 1998 Oct 23.

Article in En | MEDLINE | ID: mdl-9784130

Subject(s)

Amides/pharmacology; Receptors, Somatostatin/agonists; Amides/metabolism; Amino Acid Sequence; Animals; Cell Line; Cells, Cultured; Cricetinae; Drug Design; Glucagon/metabolism; Growth Hormone/metabolism; Insulin/metabolism; Insulin Secretion; Islets of Langerhans/drug effects; Islets of Langerhans/metabolism; Ligands; Membrane Proteins; Mice; Models, Chemical; Molecular Sequence Data; Pituitary Gland, Anterior/drug effects; Pituitary Gland, Anterior/metabolism; Rats; Receptors, Somatostatin/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Somatostatin / Amides Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: Science Year: 1998 Type: Article Affiliation country: United States

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