T lymphocyte costimulation mediated by reorganization of membrane microdomains.
Science
; 283(5402): 680-2, 1999 Jan 29.
Article
in En
| MEDLINE
| ID: mdl-9924026
ABSTRACT
Although dispensable, costimulation through CD28 facilitates activation of naïve T lymphocytes. CD28 engagement led to the redistribution and clustering of membrane and intracellular kinase-rich raft microdomains at the site of T cell receptor (TCR) engagements. Although not affecting TCR down-regulation, this process led to higher and more stable tyrosine phosphorylation of several substrates and higher consumption of Lck. These results may provide a general mechanism for amplifying receptor signaling by reorganization of membrane microdomains.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lymphocyte Activation
/
Receptors, Antigen, T-Cell
/
T-Lymphocytes
/
CD28 Antigens
/
Membrane Lipids
Limits:
Humans
Language:
En
Journal:
Science
Year:
1999
Type:
Article
Affiliation country:
Switzerland