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FACTORS ASSOCIATED WITH MORTALITY IN PATIENTS HOSPITALIZED WITH COVID-19: PROSPECTIVE COHORT AT EDGARDO REBAGLIATI MARTINS NATIONAL HOSPITAL. LIMA, PERU / FACTORES ASOCIADOS A MORTALIDAD EN PACIENTES HOSPITALIZADOS CON COVID-19: COHORTE PROSPECTIVA EN EL HOSPITAL NACIONAL EDGARDO REBAGLIATI MARTINS. LIMA, PERÚ
SciELO Preprints; set. 2020.
Preprint
in Es
| PREPRINT-SCIELO
| ID: pps-1241
Responsible library:
BR1.1
ABSTRACT
Aim:
To determine the associated factors with mortality of adult patients hospitalized with COVID-19.Methods:
We conducted a prospective cohort study and included patients older than 18 years hospitalized with the diagnosis of SARS-CoV-2 infection. Those patients with a positive rapid serological test on admission, but no respiratory symptoms nor compatible images were excluded. We collected the data from clinical records.Results:
A total of 813 adults were included, 544 (66.9%) with confirmed COVID-19. The mean age was 61.2 years (SD 15.0) and 575 (70.5%) were male. The most frequent comorbidities were hypertension (34.1%) and obesity (25.9%). The most frequent symptoms on admission were dyspnea (82.2%) and cough (53.9%). A total of 114 (14.0%) patients who received mechanical ventilation, 38 (4.7%) were admitted to the Intensive Care Unit (ICU) and 377 (46.4%) died. The requirement for ventilatory support, greater lung involvement, comorbidities, and inflammatory markers were associated with mortality. It was found that for every 10 - year increase in age, the risk of dying increased by 32% (RR 1.32 95% CI 1.25 to 1.38). Those who required admission to the ICU and mechanical ventilation had 1.39 (95% CI 1.13 to 1.69) and 1.97 (95% CI 1.69 to 2.29) times the risk of dying compared to those who did not.Conclusion:
We found a high mortality rate in hospitalized patients associated with greater age, more elevated inflammatory markers, and more severe respiratory compromise.RESUMEN
Objetivos. Determinar los factores asociados a mortalidad de los pacientes adultos hospitalizados con COVID-19 en un hospital de referencia de la seguridad social. Materiales y métodos. Se realizó un estudio de cohorte prospectivo. Se incluyó a pacientes mayores de 18 años hospitalizados con el diagnostico de infección por SARS-CoV-2 y se excluyó a quienes ingresaron asintomáticos respiratorios, con prueba rápida serológica positiva al ingreso y sin imágenes compatibles. Los datos se recolectaron a partir de la historia clínica. Resultados. Se incluyó un total de 813 adultos, 544 (66.9%) tuvieron COVID-19 confirmado. La media de la edad fue de 61.2 años (DE 15.0) y 575 (70.5%) fueron de sexo masculino. Las comorbilidades más frecuentes fueron hipertensión arterial (34.1%) y obesidad (25.9%). Los síntomas más frecuentes al ingreso fueron disnea (82.2%) y tos (53.9%). Un total de 114 (14.0%) pacientes recibieron ventilación mecánica, 38 (4.7%) ingresaron a UCI y 377 (46.4%) fallecieron. El requerimiento de soporte ventilatorio, el mayor compromiso pulmonar, las comorbilidades y los marcadores inflamatorios se asociaron a la mortalidad. Se halló que por cada 10 años que aumenta la edad, el riesgo de morir se incrementa en 32% (RR 1.32 IC95% 1.25 a 1.38). Aquellos que requirieron ingreso a UCI y ventilación mecánica tuvieron 1.39 (IC95% 1.13 a 1.69) y 1.97 (IC95% 1.69 a 2.29) veces el riesgo de morir, respectivamente. Conclusión. La mortalidad encontrada en nuestro estudio fue alta y estuvo asociada a la edad, marcadores inflamatorios y compromiso respiratorio.
Full text:
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Collection:
09-preprints
Database:
PREPRINT-SCIELO
Type of study:
Observational_studies
/
Risk_factors_studies
Country/Region as subject:
America do sul
/
Peru
Language:
Es
Year:
2020
Type:
Preprint