Modeling Methods and Clinical Fit Analysis of Animal Models of Crohn's Disease / 世界科学技术-中医药现代化

ABSTRACT

Crohn's disease(CD)is a special intestinal immune disease,and its pathogenesis has been a hotspot and difficult issue in the medical field,which cannot be cured clinically.In this paper,we summarized the characteristics of existing CD animal models and clinical diagnostic criteria of Chinese and Western medicine by compiling domestic and international research literature,and assigned values to the clinical fit of CD animal models.The results showed that there are many methods to replicate CD animal models,among which the pathology-evidence combination animal model is the more ideal choice.Most of the models were dominated by Western medicine pathogenic factors without the intervention of Chinese medicine pathogenic factors.Therefore,we can consider applying the intervention factors of Damp-Heat,Cold-Damp Trapped Spleen,Qi Stagnation and Blood Stasis,Liver Stagnation and Spleen Deficiency,and Spleen and Stomach Deficiency Cold on the basis of Western medicine pathogenic factors and differentiate them to obtain the pathogenic CD models with clinical manifestations of Chinese medicine symptoms.In addition,the success criteria of the model need to be further improved,and it is recommended to increase the quantitative scoring criteria of the animal's diet,mental status,weight,hair and feces and other apparent indicators.Improving the modeling methods and model criteria is the key to establishing an animal model of CD that highly simulates the complex pathological manifestations of clinical CD,and provides a more complete experimental research vehicle for in-depth studies of CD.