Mevalonic acid reverses the antitumor effects of fluvastatin sodium on tongue squamous cell carcinoma cells / 实用口腔医学杂志
Journal of Practical Stomatology
; (6): 227-232, 2024.
Article
in Zh
| WPRIM
| ID: wpr-1020566
Responsible library:
WPRO
ABSTRACT
Objective:
To investigate mevalonic acid(MEV)on reversing the antitumor effects of fluvastatin sodium(FS)on tongue squamous cell carcinoma(TSCC)cells.Methods:
TSCC HSC-4 cells were treated with different concentrations of FS and MEV re-spectively or in combination.Cell counting kit-8,flow cytometry,wound healing,immunofluorescence and western blotting assays were conducted to examine cell proliferation,apoptosis and migration capacities,as well as the expression levels of Ras homolog family member A(RHOA),tissue factor(TF)and B-cell lymphoma-2-associated X(BAX)proteins,respectively.Results:
FS inhibited HSC-4 cell proliferation and migration,decreased the expression of RHOA and TF,and increased BAX expression.MEV reversed the above antitumor effects of FS and promoted intracellular RHOA and TF expression.Conclusion:
MEV reverses the antitumor effects of FS on HSC-4 cells in vitro.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Journal of Practical Stomatology
Year:
2024
Type:
Article