Alterations of Cortical Folding Patterns in Patients with Bipolar I Disorder: Analysis of Local Gyrification Index
Journal of the Korean Society of Biological Psychiatry
; : 225-234, 2017.
Article
in Ko
| WPRIM
| ID: wpr-725232
Responsible library:
WPRO
ABSTRACT
OBJECTIVES:
Local gyrification reflects the early neural development of cortical connectivity, and is regarded as a potential neural endophenotype in psychiatric disorders. Several studies have suggested altered local gyrification in patients with bipolar I disorder (BD-I). The purpose of the present study was to investigate the alterations in the cortical gyrification of whole brain cortices in patients with BD-I.METHODS:
Twenty-two patients with BD-I and age and sex-matched 22 healthy controls (HC) were included in this study. All participants underwent T1-weighted structural magnetic resonance imaging (MRI). The local gyrification index (LGI) of 66 cortical regions were analyzed using the FreeSurfer (Athinoula A. Martinos Center for Biomedical Imaging). One-way analysis of covariance (ANCOVA) was used to analyze the difference of LGI values between two groups adjusting for age and sex as covariates.RESULTS:
The patients with BD-I showed significant hypogyria in the left pars opercularis (uncorrected-p = 0.049), the left rostral anterior cingulate gyrus (uncorrected-p = 0.012), the left caudal anterior cingulate gyrus (uncorrected-p = 0.033). However, these findings were not significant after applying the multiple comparison correction. Severity or duration of illness were not significantly correlated with LGI in the patients with BD-I.CONCLUSIONS:
Our results of lower LGI in the anterior cingulate cortex and the ventrolateral prefrontal cortex in the BD-I group implicate that altered cortical gyrification in neural circuits involved in emotion-processing may contribute to pathophysiology of BD-I.Key words
Full text:
1
Database:
WPRIM
Main subject:
Bipolar Disorder
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Brain
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Magnetic Resonance Imaging
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Prefrontal Cortex
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Endophenotypes
/
Broca Area
/
Gyrus Cinguli
Limits:
Humans
Language:
Ko
Journal:
Journal of the Korean Society of Biological Psychiatry
Year:
2017
Type:
Article