Serum metabolomics of preterm and full-term infants based on gas chromatography-mass spectrometry / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 259-264, 2019.
Article
in Zh
| WPRIM
| ID: wpr-774089
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To study the features of serum metabolites in preterm infants based on gas chromatography-mass spectrometry (GC-MS), and to find differentially expressed metabolites in the serum of preterm infants.@*METHODS@#Serum samples were collected from 19 preterm infants and 20 full-term infants before feeding. GC-MS was used to measure metabolic profiles, and the metabolic features of 397 serum metabolites in preterm infants were analyzed.@*RESULTS@#There was a significant difference in serum metabolic features between the preterm and full-term infants before feeding. There were significant differences between the full-term and preterm infants in the levels of metabolites such as O-phosphonothreonine, digicitrin, tannic acid, and fructose-1,6-diphosphate (P<0.01), suggesting that the above differentially expressed metabolites were highly differentiated between the preterm and full-term infants. Most differentially expressed metabolites were involved in the metabolic pathways such as ABC transporters, β-alanine and pyrimidines and were correlated with some clinical parameters (albumin and total bilirubin) (P<0.05).@*CONCLUSIONS@#There is a significant difference in serum metabolites between preterm and full-term infants before feeding. Metabolomics plays an important role in improving metabolic disorders and exploring metabolism-related diseases in preterm infants.
Full text:
1
Database:
WPRIM
Main subject:
Infant, Premature
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Metabolic Networks and Pathways
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Metabolome
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Metabolomics
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Gas Chromatography-Mass Spectrometry
Limits:
Humans
/
Newborn
Language:
Zh
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2019
Type:
Article