Value of galactose-deficient IgA1 in the early diagnosis of Henoch-Schönlein purpura nephritis in children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 172-175, 2019.
Article
in Zh
| WPRIM
| ID: wpr-774107
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To explore the value of galactose-deficient IgA1 (Gd-IgA1) in the early diagnosis of Henoch-Schönlein purpura nephritis (HSPN) in children.@*METHODS@#A total of 67 hospitalized children who were definitely diagnosed with HSPN between January and April 2018 and 58 hospitalized children with Henoch-Schönlein purpura (HSP) were enrolled in the study. Twenty children undergoing routine physical examinations served as controls. The levels of serum and urine Gd-IgA1 were determined using ELISA. The receiver operating characteristic curve was used to analyze the value of serum Gd-IgA1 and urine Gd-IgA1/urine creatinine ratio in the diagnosis of HSPN.@*RESULTS@#The level of serum Gd-IgA1 and urine Gd-IgA1/urine creatinine ratio in children with HSP or HSPN were significantly higher than those in healthy control group (P<0.01), with a significantly greater increase observed in children with HSPN (P<0.01). Serum Gd-IgA1 ≥1 485.57 U/mL and/or urine Gd-IgA1/urine creatinine ratio ≥105.74 were of favorable value in the diagnosis of HSPN. During the six-month follow-up of the 49 children with HSP, the incidence of HSPN was 47% (23/49), which included a 100% incidence in children with serum Gd-IgA1 ≥1 485.57 U/mL and a 73% incidence in children with urine Gd-IgA1/urine creatinine ratio ≥105.74.@*CONCLUSIONS@#Serum and urine Gd-IgA1 is of favorable clinical value in the early diagnosis of HSPN.
Full text:
1
Database:
WPRIM
Main subject:
IgA Vasculitis
/
Immunoglobulin A
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Early Diagnosis
/
Galactose
/
Glomerulonephritis, IGA
Type of study:
Diagnostic_studies
/
Screening_studies
Limits:
Child
/
Humans
Language:
Zh
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2019
Type:
Article