Nasal eosinophilic angiocentric fibrosis with IgG4-positive plasma cell infiltration
The Malaysian Journal of Pathology
; : 137-141, 2020.
Article
in En
| WPRIM
| ID: wpr-821458
Responsible library:
WPRO
ABSTRACT
@#Introduction:
Eosinophilic angiocentric fibrosis (EAF) is a rare lesion that predominantly affects the upper respiratory tract. Its etiology is unknown and it has been recently associated with the IgG4related disease (IgG4-RD) spectrum. To the author’s knowledge, this is the sixth case report of the relationship between EAF and IgG4-RD. Case Report We report the case of a 37-year-old woman with nasal deformity and facial pain. The lesion was surgically excised. Histological examination revealed features of EAF with an IgG4/IgG plasma cell ratio >73% and 31 IgG4 stained cells per high power field. No clinical or radiological recurrence was detected during follow-up. Serum IgG4 quantification one year after surgery was within normal limits.Discussion:
The relationship between both entities may have therapeutic impact because IgG4-RD of the head and neck has a high remission rate with corticosteroids and immunosuppressive therapy. Additional reports of this infrequent disease are necessary to elucidate appropriate treatment and prognosis.
Full text:
1
Database:
WPRIM
Type of study:
Prognostic_studies
Language:
En
Journal:
The Malaysian Journal of Pathology
Year:
2020
Type:
Article