Furoxans and tocopherol analogs-furoxan hybrids as anticancer agents
Anticancer drugs
; 30: 330-338, 2019. ilus
Article
en En
| URUCAN
| ID: bcc-5335
Biblioteca responsable:
UY78.1
Ubicación: UY78.1 BN-2370
ABSTRACT
We determined the antiproliferative and nitric oxide (NO)-releasing activity of furoxans and tocopherol analogs-furoxan hybrids by tandem Griess/resazurin/sulforhodamin B assays in HeLa, 253J, T24, and HepG2 cancer cells. In addition, to investigate the NO implications in the inhibition of cell growth, cells were pretreated with the NO scavenger hemoglobin and the genotoxic damage was determined. The compounds 1 and 3 emerged as good anticancer agents for bladder cancer treatment. The NO-releasing activity of these compounds appears to be necessary to obtain the antiproliferative effect. Although compound 1 exerted a DNA damage mechanism of action, compound 3 seemed to act in a different way. The low toxicity levels against normal cell line HaCaT point them out as a very promising scaffold for the further design of new anticancer agents(AU)
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Colección Oncologia Uruguay:
URUCAN
Banco de datos:
URUCAN
Asunto principal:
Neoplasias de la Vejiga Urinaria
/
Tocoferoles
/
Antineoplásicos
/
Óxido Nítrico
Límite:
Humans
País/Región como asunto:
America do sul
/
Uruguay
Idioma:
En
Revista:
Anticancer drugs
Año:
2019
Tipo del documento:
Article