Results of high-risk neutropenia therapy of hematology-oncology patients in a university hospital in Uruguay
Rev. bras. hematol. hemoter
; 37(1): 28-33, Jan-Feb/2015. tab, graf
Article
en En
| LILACS
| ID: lil-741869
Biblioteca responsable:
BR408.1
Ubicación: BR408.1
ABSTRACT
Background:
Febrile neutropenia is an important cause of mortality and morbidity in hematology-oncology patients undergoing chemotherapy. The management of febrile neutropenia is typically algorithm-driven. The aim of this study was to assess the results of a standardized protocol for the treatment of febrile neutropenia.Methods:
A retrospective cohort study (2011-2012) was conducted of patients with high-risk neutropenia in a hematology-oncology service.Results:
Forty-four episodes of 17 patients with a median age of 48 years (range 18-78 years) were included. The incidence of febrile neutropenia was 61.4%. The presence of febrile neutropenia was associated with both the duration and severity of neutropenia. Microbiological agents were isolated from different sources in 59.3% of the episodes with bacteremia iso- lated from blood being the most prevalent (81.3%). Multiple drug-resistant gram-negative bacilli were isolated in 62.5% of all microbiologically documented infections. Treatment of 63% of the episodes in which the initial treatment was piperacillin/tazobactam needed to be escalated to meropenem. The mortality rate due to febrile neutropenia episodes was 18.5%.Conclusion:
The high rate of gram-negative bacilli resistant to piperacillin/tazobactam (frontline antibiotics in our protocol) and the early need to escalate to carbapenems raises the question as to whether it is necessary to change the current protocol. .Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
LILACS
Asunto principal:
Resistencia a Medicamentos
/
Protocolos Clínicos
/
Infecciones por Bacterias Gramnegativas
/
Farmacorresistencia Bacteriana
/
Enfermedades Hematológicas
/
Neutropenia
Tipo de estudio:
Etiology_studies
/
Guideline
/
Observational_studies
/
Risk_factors_studies
Límite:
Humans
País/Región como asunto:
America do sul
/
Uruguay
Idioma:
En
Revista:
Rev. bras. hematol. hemoter
Asunto de la revista:
HEMATOLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Uruguay