Thyroglobulin binding and TSH regulation of the RHL-1 subunit of the asialoglycoprotein receptor in rat thyroid.
Biochimie
; 81(5): 493-6, 1999 May.
Article
en En
| MEDLINE
| ID: mdl-10403180
ABSTRACT
The ability of asialo-thyroglobulin to bind the thyroid RHL-1 subunit of the asialoglycoprotein receptor has been investigated. Ligand blot assays show that the recombinant carbohydrate recognition domain of the thyroid RHL-1 subunit specifically interacts with rat desialated thyroglobulin. Moreover, RT-PCR and Western blot assays show that TSH deprivation decreases RHL-1 expression in PC C13 thyroid differentiated cells whereas insulin deprivation does not have any effect. The simultaneous absence of both TSH and insulin dramatically decreases the level of RHL-1 expression.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Asialoglicoproteínas
/
Tiroglobulina
/
Glándula Tiroides
/
Tirotropina
/
Receptores de Superficie Celular
Límite:
Animals
Idioma:
En
Revista:
Biochimie
Año:
1999
Tipo del documento:
Article
País de afiliación:
Italia