P53 genotyping - an effective concept for molecular testing of head and neck cancer?
Int J Mol Med
; 4(3): 279-83, 1999 Sep.
Article
en En
| MEDLINE
| ID: mdl-10425279
ABSTRACT
P53 mutations are currently recognized as the most common genetic alteration in human tumors. The purpose of our study was to evaluate the significance and reliability of p53 genotyping in head and neck cancer as a possible marker permitting the prediction of tumor behavior and clinical outcome. P53 genotyping in our study refers to highly sensitive molecular screening in order to detect structural alterations in the nucleic acid sequence of the gene. Exons 2-11 and adjacent intronic regions were screened for mutations by direct genomic sequencing or by bi-directional dideoxyfingerprinting in 66 primary tumors of the larynx, pharynx and oral cavity. Alterations in the
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Genes p53
/
Neoplasias de Cabeza y Cuello
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Int J Mol Med
Asunto de la revista:
BIOLOGIA MOLECULAR
/
GENETICA MEDICA
Año:
1999
Tipo del documento:
Article
País de afiliación:
Alemania