Adrenomedullin selectively inhibits angiotensin II-induced aldosterone secretion in humans.
J Hypertens
; 18(1): 61-4, 2000 Jan.
Article
en En
| MEDLINE
| ID: mdl-10678544
ABSTRACT
OBJECTIVE:
Adrenomedullin inhibits angiotensin II stimulated aldosterone production in vitro and in vivo in experimental animals. The aim of this study was to investigate the effect of adrenomedullin on angiotensin II and adrenocorticotrophic hormone-stimulated aldosterone production in vivo in healthy humans. DESIGN ANDMETHODS:
Seven volunteers were studied in a quiet, temperature-controlled laboratory. After 35 min of rest, an infusion of placebo or adrenomedullin (3 pmol/kg per min) was given over 60 min; 15 min after starting this first infusion, a second infusion of angiotensin II (0.96 fmol/kg per min) or adrenocorticotrophic hormone (0.1 mIU/kg per min) was co-infused and continued for 45 min.RESULTS:
Adrenomedullin significantly inhibited angiotensin II stimulated aldosterone production the increment in aldosterone on the placebo day was 691 pmol/l compared with 552 pmol/l on the adrenomedullin day (P< 0.004). Adrenomedullin did not inhibit adrenocorticotrophic hormone-stimulated aldosterone or cortisol release.CONCLUSION:
Adrenomedullin selectively inhibits angiotensin II-stimulated aldosterone production.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Péptidos
/
Angiotensina II
/
Aldosterona
/
Antagonistas de Receptores de Mineralocorticoides
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Hypertens
Año:
2000
Tipo del documento:
Article
País de afiliación:
Reino Unido