L-arginine and L-NAME have no effects on the reendothelialization process after arterial balloon injury.
Cardiovasc Res
; 43(3): 731-8, 1999 Aug 15.
Article
en En
| MEDLINE
| ID: mdl-10690344
ABSTRACT
OBJECTIVE:
Growth regulatory properties of nitric oxide (NO) in cultured endothelial cells is controversial. The aim of our study was to investigate the effect of L-arginine, the endogenous NO precursor, and L-NAME, an inhibitor of NO synthase on the reendothelialization process after angioplasty.METHODS:
Fifty-five New Zealand White rabbits underwent denudation of the left iliac artery. After injury the rabbits were randomized in three groups L-arginine 2.25% (L-arginine, n = 19); NG-nitro-L-arginine methyl ester 15 mg/kg/day (L-NAME, n = 19); and placebo (controls, n = 17). Treatment was solubilized in drinking water. Reendothelialization was evaluated at 4 weeks by macroscopic evaluation of Evans blue staining and endothelial-specific immunostaining (CD-31) on cross sections. Intimal hyperplasia was evaluated by morphometric analysis.RESULTS:
Despite a significant increase in plasma arginine (P = 0.001) and a reduction in intimal hyperplasia (P = 0.003) with L-arginine, neither agent had a significant effect on reendothelialization at 4 weeks (controls = 36 +/- 4%, L-arginine = 43 +/- 3%, L-NAME = 33 +/- 4%; NS).CONCLUSION:
These results suggest that, in spite of previously demonstrated effects on neointimal hyperplasia, the NO pathway does not influence the regrowth of macrovascular endothelial cells in vivo.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Arginina
/
Endotelio Vascular
/
Cateterismo
/
Óxido Nítrico Sintasa
/
NG-Nitroarginina Metil Éster
/
Inhibidores Enzimáticos
Límite:
Animals
Idioma:
En
Revista:
Cardiovasc Res
Año:
1999
Tipo del documento:
Article
País de afiliación:
Francia