Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors.
Science
; 291(5501): 134-7, 2001 01 05.
Article
en En
| MEDLINE
| ID: mdl-11141566
ABSTRACT
Most traditional cytotoxic anticancer agents ablate the rapidly dividing epithelium of the hair follicle and induce alopecia (hair loss). Inhibition of cyclin-dependent kinase 2 (CDK2), a positive regulator of eukaryotic cell cycle progression, may represent a therapeutic strategy for prevention of chemotherapy-induced alopecia (CIA) by arresting the cell cycle and reducing the sensitivity of the epithelium to many cell cycle-active antitumor agents. Potent small-molecule inhibitors of CDK2 were developed using structure-based methods. Topical application of these compounds in a neonatal rat model of CIA reduced hair loss at the site of application in 33 to 50% of the animals. Thus, inhibition of CDK2 represents a potentially useful approach for the prevention of CIA in cancer patients.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sulfonamidas
/
Proteínas Serina-Treonina Quinasas
/
Quinasas Ciclina-Dependientes
/
Folículo Piloso
/
Quinasas CDC2-CDC28
/
Inhibidores Enzimáticos
/
Alopecia
/
Indoles
/
Antineoplásicos
Idioma:
En
Revista:
Science
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos