Quantifiable dose-dependent withdrawal after morphine discontinuation in a rat model.
Pharmacol Biochem Behav
; 68(1): 1-6, 2001 Jan.
Article
en En
| MEDLINE
| ID: mdl-11274701
ABSTRACT
We evaluated the intensity of the withdrawal symptoms after the discontinuation of the morphine infusion in rats. Opiate addiction was induced by progressively increasing intraperitoneal morphine infusion rates. The control group (Group 1) received normal saline. The initial morphine rates were 1, 4, and 16 mg kg(-1) h for Groups 2, 3, and 4, respectively. Infusion rates were gradually increased by a factor of 1.4, 2, 2.8, and 4 on the second, third, fourth, and fifth days, respectively. The last rate was used for 48 h and then infusions were disconnected. Weight reduction, food consumption, and water intake were used for evaluation of withdrawal. All morphine groups showed a significant reduction of body weight during the 4 postdiscontinuation days and a decline in food and water intake on the first postdiscontinuation day. All changes were dependent on the morphine infusion concentration. No changes were observed in the control group. We suggest that the rat model used in this study may be utilized for quantification of spontaneous withdrawal.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Síndrome de Abstinencia a Sustancias
/
Morfina
/
Dependencia de Morfina
/
Narcóticos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Pharmacol Biochem Behav
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos