Molecular genetics of vascular malformations.
Matrix Biol
; 20(5-6): 327-35, 2001 Sep.
Article
en En
| MEDLINE
| ID: mdl-11566267
ABSTRACT
Vascular malformations are localized errors of angiogenic development. Most are cutaneous and are called vascular 'birthmarks'. These anomalies are usually obvious in the newborn, grow commensurately with the child, and gradually expand in adulthood (Mulliken and Glowacki, 1982). Vascular malformations also occur in visceral organs, such as the respiratory and gastrointestinal tract, but are more common in the brain (Mulliken and Young, 1988). These anomalies are composed of tortuous vascular channels of varying size and shape, lined by a continuous endothelium and surrounded by abnormal complement of mural cells. Vascular malformation can be life threatening due to obstruction, bleeding or congestive heart failure. Most anomalies occur sporadically, but there are families exhibiting autosomal dominant inheritance. Genetic studies of such families have resulted in the identification of mutated genes, directly giving proof of their important role in the regulation of angiogenesis.
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Malformaciones Arteriovenosas
/
Piel
/
Venas
/
Capilares
/
Aberraciones Cromosómicas
/
Malformaciones Vasculares del Sistema Nervioso Central
/
Linfedema
/
Mutación
Límite:
Humans
Idioma:
En
Revista:
Matrix Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Bélgica