Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling.
Science
; 294(5551): 2511-5, 2001 Dec 21.
Article
en En
| MEDLINE
| ID: mdl-11752569
ABSTRACT
The circadian clock in the suprachiasmatic nucleus (SCN) is thought to drive daily rhythms of behavior by secreting factors that act locally within the hypothalamus. In a systematic screen, we identified transforming growth factor-alpha (TGF-alpha) as a likely SCN inhibitor of locomotion. TGF-alpha is expressed rhythmically in the SCN, and when infused into the third ventricle it reversibly inhibited locomotor activity and disrupted circadian sleep-wake cycles. These actions are mediated by epidermal growth factor (EGF) receptors on neurons in the hypothalamic subparaventricular zone. Mice with a hypomorphic EGF receptor mutation exhibited excessive daytime locomotor activity and failed to suppress activity when exposed to light. These results implicate EGF receptor signaling in the daily control of locomotor activity, and identify a neural circuit in the hypothalamus that likely mediates the regulation of behavior both by the SCN and the retina.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sueño
/
Núcleo Supraquiasmático
/
Ritmo Circadiano
/
Receptores ErbB
/
Hipotálamo
/
Actividad Motora
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos