Trisomy 13 or 18 (mosaicism) in first trimester cytotrophoblast cells: false-positive results in 11 out of 51 cases.
Eur J Obstet Gynecol Reprod Biol
; 101(2): 161-8, 2002 Mar 10.
Article
en En
| MEDLINE
| ID: mdl-11858892
ABSTRACT
OBJECTIVE:
The finding of full or mosaic trisomy 13 or 18 in first trimester chorionic villus sampling (CVS) may be a false-positive result. This report provides incidence and outcome information that may be helpful in counselling individual patients and in choosing adequate follow-up. STUDYDESIGN:
From a series of 6820 CVS cases, we retrospectively collected data on all patients (n=51) with full (n=30) or mosaic (n=5) trisomy 18, and full (n=13) or mosaic (n=3) trisomy 13 in cytotrophoblast cells.RESULTS:
Five false-positives were seen in patients with full trisomy 18 and three in the mosaic cases. One false-positive result was observed in full trisomy 13 and two false-positives in cases of mosaicism. No false-negative results were reported.CONCLUSION:
The diagnosis of trisomy 13 or 18 in cytotrophoblasts should be confirmed in other tissues, unless fetal abnormalities are seen at ultrasound. In case of mosaicism, follow-up amniocentesis is advised.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Primer Trimestre del Embarazo
/
Trisomía
/
Cromosomas Humanos Par 13
/
Cromosomas Humanos Par 18
/
Muestra de la Vellosidad Coriónica
/
Reacciones Falso Positivas
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Eur J Obstet Gynecol Reprod Biol
Año:
2002
Tipo del documento:
Article
País de afiliación:
Países Bajos