The structure, regulation, and function of human matrix metalloproteinase-13.
Crit Rev Biochem Mol Biol
; 37(3): 149-66, 2002.
Article
en En
| MEDLINE
| ID: mdl-12139441
ABSTRACT
Matrix metalloproteinase-13 (MMP-13) is a proteolytic enzyme that belongs to a large family of extracellular matrix-degrading endopeptidases that are characterized by a zinc-binding motif at their catalytic sites. MMP-13 has a key role in the MMP activation cascade and appears to be critical in bone metabolism and homeostasis. It also has an important role in tumor invasion and metastasis. This commentary provides a detailed overview of the regulatory mechanisms, structure, and function of human MMP-13 and highlights the key factors involved in the biology of this important molecule.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Regulación Enzimológica de la Expresión Génica
/
Colagenasas
Límite:
Humans
Idioma:
En
Revista:
Crit Rev Biochem Mol Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Año:
2002
Tipo del documento:
Article
País de afiliación:
Reino Unido