The effect of transient intestinal ischemia on inflammatory parameters.
Int J Colorectal Dis
; 18(1): 78-85, 2003 Jan.
Article
en En
| MEDLINE
| ID: mdl-12458386
ABSTRACT
BACKGROUND AND AIMS:
To determine the early biological changes occurring in intestinal ischemia in vivo. PATIENTS ANDMETHODS:
We studied the effects of acute transient intestinal ischemia in 15 patients undergoing elective open surgery for the treatment of abdominal subrenal aortic aneurysm induced by clamping of the aorta at subrenal level and above the branching of the inferior mesenteric artery. Blocking the blood flow results in hypoperfusion of the inferior mesenteric artery and then to rectal mucosal ischemia.RESULTS:
With the introduction of a mucosal ischemic period the basal intestinal mucosal pH decreased during ischemia, and showed a rapid increase during reperfusion to the level preceding ischemia. Parameters were evaluated in blood taken from inferior mesenteric vein. A rectal dialysis was put into the rectum to evaluate eicosanoid concentrations in rectal fluid collected before and during clamping and after declamping. Significant enhancement in plasma level of xanthine, a marker for tissue damage, was observed during reperfusion. Interleukin-6 levels were significantly elevated from 11.28+/-3.4 pg/ml (preischemic) to 109+/-85.9 pg/ml (ischemic) and to 189.33+/-120.24 pg/ml (reperfusion); and tromboxane B(2) levels from 141.57+/-51.20 pg/ml preoperation to 473.01+/-319.01 pg/ml during the surgical procedure.CONCLUSION:
These observations indicate that even transient ischemia modifies the inflammatory pattern.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Colitis Isquémica
/
Mediadores de Inflamación
Tipo de estudio:
Evaluation_studies
Límite:
Aged
/
Humans
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Int J Colorectal Dis
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Italia