Large neutral amino acid therapy and phenylketonuria: a promising approach to treatment.
Mol Genet Metab
; 79(2): 110-3, 2003 Jun.
Article
en En
| MEDLINE
| ID: mdl-12809641
ABSTRACT
Six subjects with classical phenylketonuria (PKU) were treated with large neutral amino acid supplements (PreKUnil, Nilab, Dk) at 0.4g/kg/day in equally divided doses three times each day on an increased natural protein diet. All six subjects had low or deficient blood concentrations of both tyrosine and tryptophan, which are precursors for dopamine and serotonin, respectively, at the beginning of the study and were increased substantially throughout the study. Blood phenylalanine concentrations remained essentially unchanged, while the brain phenylalanine concentrations gradually decreased toward the carrier range as seen in parents of children with PKU. Two subjects were diagnosed with clinical depression and were in counseling programs at initiation of the study. At the end of the study all patients reported increased energy and overall improvement in well-being.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fenilcetonurias
/
Aminoácidos
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Mol Genet Metab
Asunto de la revista:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
/
METABOLISMO
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos