Targeting genetically modified macrophages to the glomerulus.
Nephron Exp Nephrol
; 94(4): e113-8, 2003.
Article
en En
| MEDLINE
| ID: mdl-12972709
ABSTRACT
Macrophages are key players in the development of the majority of renal diseases and are therefore ideal cellular vectors for site specifically targeting gene therapy to inflamed glomeruli. Macrophages can be genetically modified using viral vectors ex vivo then re-introduced into the body where they can home to the diseased site. This review summarises current experience in efficiently targeting modified macrophages to the inflamed glomerulus focussing on the factors controlling macrophage localisation, macrophage gene transfer methods, in vivo gene delivery and results of recent investigations using modified macrophage gene therapy for glomerular disease.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Movimiento Celular
/
Glomérulos Renales
/
Activación de Macrófagos
/
Macrófagos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nephron Exp Nephrol
Asunto de la revista:
NEFROLOGIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Reino Unido