Investigation of chromatographic conditions for the separation of cefuroxime axetil and its geometric isomer.
J Chromatogr B Analyt Technol Biomed Life Sci
; 800(1-2): 175-9, 2004 Feb 05.
Article
en En
| MEDLINE
| ID: mdl-14698252
ABSTRACT
The optimal chromatographic conditions for the separation of the syn- and anti-geometric isomers of cefuroxime axetil applying RP-HPLC and micellar liquid chromatography (MLC) methods were investigated. The possibility to separate diastereoisomers of syn- and anti-cefuroxime axetil was observed. Investigations were performed using three columns, two classical silicas and one with hybrid particle technology. Three aqueous-organic and one micellar mobile phases were used. The best results were achieved using micellar mobile phase. Optimization study was performed using different micellar mobile phases. MLC method is sensitive and applicable in purity and stability testing.
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cefuroxima
Idioma:
En
Revista:
J Chromatogr B Analyt Technol Biomed Life Sci
Asunto de la revista:
ENGENHARIA BIOMEDICA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Yugoslavia