The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells.
J Exp Med
; 199(7): 1025-31, 2004 Apr 05.
Article
en En
| MEDLINE
| ID: mdl-15067037
ABSTRACT
The role of CD40 ligand (CD40L)/CD40 signaling in T cell-dependent B cell differentiation and maturation has been amply documented. The mechanism of CD40 signaling in B cells has been well established, whereas the signaling mechanism of CD40L in T cell costimulation remains unknown. In this study we show that CD28i, a transmembrane splice variant of CD28 costimulatory receptor, complexes with CD40L in human T cells. The cross-linking of CD40L resulted in the coendocytosis of CD28i with CD40L. The tyrosine phosphorylation of CD28i followed the cross-linking of CD40L, and the overexpression of CD28i augmented the c-Jun NH2-terminal kinase, p21-activated kinase 2, and nuclear factor kappaB activation. These data indicate that CD28i, by functioning as a signaling adaptor, transduces CD40L signaling as well as CD28 signaling in human T cells.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos T
/
Antígenos CD28
/
Ligando de CD40
Límite:
Humans
Idioma:
En
Revista:
J Exp Med
Año:
2004
Tipo del documento:
Article
País de afiliación:
Canadá