Characterization of a novel DQB1 allele associated with HLA-DQw3: implications for oligotyping.
Hum Immunol
; 33(3): 224-7, 1992 Mar.
Article
en En
| MEDLINE
| ID: mdl-1618660
ABSTRACT
During HLA-DQ oligotyping, the presence of a novel HLA-DQB1 allele was suggested by a pattern of probe hybridization that was inconsistent with the presence of any possible combination of two known alleles. The nucleotide sequence of the second exon of the HLA-DQB1 gene was determined, revealing a novel HLA-DQB1 sequence differing from the DQB1*0301 allele by a single nucleotide substitution at codon 57. All published HLA-DQ oligotyping systems could assign inaccurate oligotypes when this allele is present. An additional amplification primer was utilized to achieve discrimination of all possible combinations of known HLA-DQB1 alleles.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Antígenos HLA-DQ
/
Alelos
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Hum Immunol
Año:
1992
Tipo del documento:
Article