Erythrocyte aggregation in Behçet's disease determined with the Sefam and Myrenne aggregometer. Lack of association with thrombosis and uveitis.
Clin Hemorheol Microcirc
; 33(4): 389-96, 2005.
Article
en En
| MEDLINE
| ID: mdl-16317248
ABSTRACT
Behçet's disease (BD) is a chronic systemic vasculitis characterised by recurrent oral and genital ulcers and uveitis, in which 25-30% of patients develop thrombotic events of unknown etiology. In order to ascertain whether erythrocyte aggregation (EA) may be involved in thrombotic events and or uveitis in BD patients, we determined using two erythrocyte aggregometers i.e. Myrenne and Sefam (which provides the total disaggregation threshold, needed for erythrocytes to disaggregate), EA in 77 BD patients (42 male, 35 female, aged 44 +/- 12 years) and 77 controls (41 male, 36 female, aged 43 +/- 11 years). BD patients showed higher EA determined with both aggregometers Myrenne (EA(0) P = 0.035; EA(1) P < 0.001) or the Sefam (Ta P < 0.001, AI(10) P < 0.001, gammaD P = 0.014) as well as higher fibrinogen and triglyceride levels (P < 0.001, P = 0.003, respectively) compared with the control group. However no differences were observed in any of the aggregation parameters determined either with the Myrenne (EA(0), EA(1)) or the Sefam (Ta, AI(10), gammaD) aggregometer when BD patients with thrombotic events (n = 23) or uveitis (n = 21) were compared with those who did not (P > 0.05). These results reinforce previous findings of our group, suggesting that EA does not seem to be involved in thrombotic events or in uveitis in BD patients.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Uveítis
/
Síndrome de Behçet
/
Agregación Eritrocitaria
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Hemorheol Microcirc
Asunto de la revista:
ANGIOLOGIA
/
HEMATOLOGIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
España