Vanadyl causes hydroxyl radical mediated degradation of deoxyribose.
Free Radic Res Commun
; 14(5-6): 335-42, 1991.
Article
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| MEDLINE
| ID: mdl-1663905
ABSTRACT
Vanadyl caused a time- and dose-dependent degradation of deoxyribose to carbonyl products detectable with thiobarbituric acid. This process was inhibited by catalase, ethanol or HEPES; whereas superoxide dismutase was without effect. Vanadate did not substitute for vanadyl even in the presence of a source of O2- plus H2O2; but it did so in the presence of reductants such as thiols or NADH. It appears that hydrogen peroxide, generated by the autoxidation of vanadyl, is reduced by vanadyl to the hydroxyl radical; which, in turn, was responsible for the degradation of deoxyribose. A similar process might contribute to the toxic and pharmacological effects of vanadium salts.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Vanadatos
/
Desoxirribosa
/
Hidróxidos
Tipo de estudio:
Etiology_studies
Idioma:
En
Revista:
Free Radic Res Commun
Asunto de la revista:
QUIMICA
Año:
1991
Tipo del documento:
Article