Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox.
Science
; 251(4998): 1239-43, 1991 Mar 08.
Article
en En
| MEDLINE
| ID: mdl-1672471
ABSTRACT
The two mouse genes, En-1 and En-2, that are homologs of the Drosophila segmentation gene engrailed, show overlapping spatially restricted patterns of expression in the neural tube during embryogenesis, suggestive of a role in regional specification. Mice homozygous for a targeted mutation that deletes the homeobox were viable and showed no obvious defects in embryonic development. This may be due to functional redundancy of En-2 and the related En-1 gene product during embryogenesis. Consistent with this hypothesis, the mutant mice showed abnormal foliation in the adult cerebellum, where En-2, and not En-1, is normally expressed.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cerebelo
/
Genes Homeobox
/
Deleción Cromosómica
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1991
Tipo del documento:
Article
País de afiliación:
Canadá