Methyl group metabolism gene polymorphisms as modifier of breast cancer risk in Italian BRCA1/2 carriers.
Breast Cancer Res Treat
; 103(1): 29-36, 2007 May.
Article
en En
| MEDLINE
| ID: mdl-17151928
ABSTRACT
BRCA1 and 2 are major cancer susceptibility genes but their penetrance is highly variable. The folate metabolism plays an important role in DNA methylation and its alterated metabolism is associated with cancer risk. The role of allele variants 677T and 1298C (MTHFR gene) and 2756G (MS gene) has been investigated as potentially modifying factors of BRCA gene penetrance, evaluated as age at first diagnosis of cancer, in 484 BRCA1/BRCA2 carriers and in 108 sporadic breast cancer cases as a control group. The genotype analysis has been performed by means of PCR/RFLP's. The analysis of association between a particular genotype and disease risk was performed using Cox Regression with time to breast or ovarian cancer onset as the end-point. The presence of 677T allele confers an increased risk of breast cancer in BRCA1 carriers (P = 0.007) and the presence of 1298C allele confers an increased risk of breast cancer in sporadic cases (P = 0.015).
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
5-Metiltetrahidrofolato-Homocisteína S-Metiltransferasa
/
Neoplasias de la Mama
/
Genes BRCA1
/
Predisposición Genética a la Enfermedad
/
Genes BRCA2
/
Metilenotetrahidrofolato Reductasa (NADPH2)
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Breast Cancer Res Treat
Año:
2007
Tipo del documento:
Article
País de afiliación:
Italia