[Oral cytology: historical development, current status, and perspectives]. / Orale Zytologie: Historische Entwicklung, aktueller Stand und Ausblick.
Mund Kiefer Gesichtschir
; 11(1): 1-9, 2007 Jan.
Article
en De
| MEDLINE
| ID: mdl-17177045
ABSTRACT
Oral cytology has aroused new interest caused by introduction of the cytobrush as a sampling device and the use of additional analytical methods. By brushing it is possible to reach deeper layers of the oral mucosa where squamous intraepithelial neoplasia (SIN) begins. The biological potential of the oral epithelial cells obtained can be evaluated by the following additional methods:
computer-assisted image analysis (OralCDx), DNA cytometry, immunohistochemistry, monolayer cytology, and molecular biological analysis. All of those methods can increase sensitivity (up to 100%) and specificity (up to 100%) of oral brush biopsy. Nevertheless, there are reports that oral epithelial carcinomas were not identified. No comparative study exists allowing conclusions to be drawn about the value of the single methods. Immunocytochemistry with commercial antibodies against laminin-5 is generally available and methodologically easy. Oral brush biopsy as a non invasive diagnostic method can be useful for the early detection of oral mucosal lesions. Positive findings or progression of the lesion despite negative findings are indications to refer the patient to a specialized clinic where a surgical biopsy should be performed, followed by histopathological analysis. Histopathology remains the gold standard for the definitive diagnosis of oral malignant lesions.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Boca
/
Carcinoma in Situ
/
Carcinoma de Células Escamosas
/
Técnicas Citológicas
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Límite:
Humans
Idioma:
De
Revista:
Mund Kiefer Gesichtschir
Asunto de la revista:
ODONTOLOGIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Alemania