Retrospective analysis of a new antibiotic chemoprophylaxis regimen in 170 patients undergoing endoscopic endonasal transsphenoidal surgery.
Surg Neurol
; 68(2): 145-8; discussion 148, 2007 Aug.
Article
en En
| MEDLINE
| ID: mdl-17537487
ABSTRACT
BACKGROUND:
The aim of this study is to evaluate the rate of infectious complications post endoscopic transspheinodal neurosurgery in patients receiving a new antibiotic chemoprophylaxis regimen.METHODS:
Clinical records of 170 patients who received prophylaxis with a third-generation cephalosporin plus aminoglycoside (160 cases) or alone (10 cases) were retrospectively analyzed. Twenty-eight patients (16.4%) had CSF leakage. The postsurgical follow-up ranged from 3 months to 4 years.RESULTS:
Of 170 patients, 2 (1.17%) developed infectious complications 1 case of meningitis by Staphylococcus epidermidis and 1 case of sphenoid sinusitis (without microbiological diagnosis). In addition, asymptomatic sphenoid sinusitis was diagnosed in 2 other patients. The cost ranged from 22.50 to 33.34 euros/d.CONCLUSIONS:
The rate of infectious complications was very low in patients receiving prophylaxis with a third-generation cephalosporin plus aminoglycoside or alone; because of the broad-spectrum of antibiotics and their high cost, this regimen could be used in at-risk patients (eg, smokers, patients with cerebrospinal leak, or patients with Cushing diseases).
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Infección de la Herida Quirúrgica
/
Ceftriaxona
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Amicacina
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Ceftazidima
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Profilaxis Antibiótica
/
Antibacterianos
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Surg Neurol
Año:
2007
Tipo del documento:
Article
País de afiliación:
Italia