Persistent akinetic-rigid side effects of neuroleptics may indicate Wilson's disease.
Ideggyogy Sz
; 60(9-10): 404-5, 2007 Sep 30.
Article
en En
| MEDLINE
| ID: mdl-17987735
ABSTRACT
Here we report two cases, where neuroleptic treatment provoked persistent akinetic-rigid symptoms resulting in the diagnosis of Wilson's disease. No liver function abnormalities suggested Wilson's disease in one of the cases. In both cases, the akinetic-rigid symptoms were originally attributed to side effects of neuroleptics, but symptoms persisted after discontinuation of treatment. In one of the cases, T2-weighted cranial MRI indicated bilateral hyperintense signals in the basal ganglia. Our cases suggest that in a subgroup of Wilson's disease, dopamine receptor antagonists may provoke akinetic-rigid neurological symptoms possibly due to the damage of dopaminergic neurons. Persistent akinetic-rigid side effects of neuroleptics in young patients thus require diagnostic tests to exclude Wilson's disease even in unsuspected cases.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Antipsicóticos
/
Ganglios Basales
/
Degeneración Hepatolenticular
/
Rigidez Muscular
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Ideggyogy Sz
Año:
2007
Tipo del documento:
Article