Preferential coxsackievirus replication in proliferating/activated cells: implications for virus tropism, persistence, and pathogenesis.
Curr Top Microbiol Immunol
; 323: 149-73, 2008.
Article
en En
| MEDLINE
| ID: mdl-18357769
ABSTRACT
Coxsackieviruses cause substantial human morbidity and mortality, but the underlying molecular mechanisms of disease remain obscure. Here, we review the effects that the cell status--both cellular activation, and the cell cycle--may have on the outcome of virus infection. We propose that these viruses have evolved to undergo productive infection in cells at the G1/S stage of the cell cycle, and to preferentially establish persistence/latent infection in quiescent cells, and we provide possible explanations for these outcomes. Finally, we consider the implications of these interactions for virus transmission and host pathology.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Replicación Viral
/
Ciclo Celular
/
Enterovirus
/
Infecciones por Coxsackievirus
/
Proliferación Celular
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Top Microbiol Immunol
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos